反应详情

This was prepared from 4-(3,4-dichlorophenyl)-2-((dimethylamino)methylene)-3,4-dihydronaphthalen-1(2H)-one and tert-butyl 4-guanidinopiperidine-1-carboxylate hydrochloride salt under the condition described in the general procedure 1 to afford tert-butyl 4-(6-(3,4-dichlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)piperidine-1-carboxylate (0.68 g) as a light yellow solid. M.p.=94-96° C. 1H NMR 400 MHz (DMSO-d6) δ 8.27-8.25 (m, 1 H), 8.13 (s, 1 H), 7.52 (d, J=8.4 Hz, 1 H), 7.47-7.40 (m, 3 H), 7.08-7.00 (m, 3 H), 4.40 (t, J=6.4 Hz, 1 H), 3.94 (bd, 2 H), 3.22-3.03 (m, 2 H), 2.90-2.85 (m, 2 H), 1.89-1.86 (m, 2 H), 1.42-1.34 (m, 12 H). LCMS m/e 525 (M+H).