Potassium Carbonate → HCID 67604482, compound

HRID 1810Notes

Reaction equation

HRID 1810 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])[C:9]([CH:11]=[CH:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:10])=[C:4]([CH:23]([OH:40])[C:24]2[CH:29]=[CH:28][C:27]([O:30][CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:26][C:25]=2[O:38][CH3:39])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH2:31]([O:30][C:27]1[CH:28]=[CH:29][C:24]([C@@H:23]2[C:4]3[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=3[N:8]([CH2:18][C:19]([CH3:21])([CH3:22])[CH3:20])[C:9](=[O:10])[C@@H:11]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[O:40]2)=[C:25]([O:38][CH3:39])[CH:26]=1)[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 67604576ethyl 3-[N-[4-chloro-2-(4-benzyloxy-alpha-hydroxy-2-methoxybenzyl)-phenyl]-N-neopentylcarbamoyl]acrylate

Product 1

HCID 67604482HCID 67604482, compoundYield 81.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of ethyl 3-[N-[4-chloro-2-(4-benzyloxy-α-hydroxy-2-methoxybenzyl)-phenyl]-N-neopentylcarbamoyl]acrylate (12 g), potassium carbonate (5.9 g) and ethanol (150 ml) was stirred for 24 h. After the mixture was concentrated in vacuo, the residue was diluted with water (200 ml) and extracted with ethyl acetate (200 ml). The extract was washed with water, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1) to give ethyl trans-5-(4-benzyloxy-2-methoxyphenyl)-7-chloro-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetate (9.8 g) as needles (mp=130°-131° C.).

Workup

  1. concentrationAfter the mixture was concentrated in vacuo
  2. additionthe residue was diluted with water (200 ml)
  3. extractionextracted with ethyl acetate (200 ml)
  4. washThe extract was washed with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated in vacuo
  7. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1)

Sources & evidence

ORD record
ord-0bc1a7edcd584f338aa5705126d111be
Source dataset
uspto-grants-1998_03
Patent number
US05726306

Reaction notes

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