反应详情

is prepared according to example 4c starting from 1-(4-hydroxyphenyl)-2-phenyl ethanone (prepared according examples 4a-b)(10.0 g, 47.1 mmol) and 2-(2-benzyloxyethoxy)ethyl chloride (11.0 g, 51.8 mmol). The product was triturated three times with warm heptane to remove byproducts. Yield 9.6 g, 52%. 1H NMR (CDCl3): 3.60-3.79 (m, 4H), 3.85 (dist.t, 2H), 4.16 (dist.t, 2H), 4.20 (s, 2H), 4.56 (s, 2H), 6.92 (d, 2H), 7.20-7.41 (m, 10H), 7.96 (d, 2H).

1. customis prepared
2. customThe product was triturated three times with warm heptane
3. customto remove byproducts