反应详情

Ethyl (±)-3-(5-methylthiazol-2-yl)-4-(benzyloxyphenyl)crotonate (0.99 mmole, crude) was dissolved in MeOH (5 mL), and magnesium turnings (120 mg, 4.95 mmole) were added at RT. After 72 hr the mixture was poured into 10% HCl (75 mL) and extracted with CH2Cl2 (3×50 mL). The combined organic layers were dried over MgSO4, filtered, and concentrated to afford the crude title compound. This was used without purification: MS (ES) m/e 382 (M+H)+.

1. extractionextracted with CH2Cl2 (3×50 mL)
2. dry with materialThe combined organic layers were dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated