反应详情

1-[(dimethylamino)carbonyl]-4-methoxy-6-(4-methoxybenzyl)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yl acetate (7.55 g) was dissolved in 50 mL MeOH and treated with 6.65 mL of a 30% by weight solution of NaOMe in MeOH at room temperature for 30 minutes. The reaction was concentrated and the remaining solid partitioned between 10% KHSO4 and chloroform. The organic layer was washed with brine, dried over Na2SO4, and then concentrated to pure product by HPLC/MS and NMR.

1. concentrationThe reaction was concentrated
2. customthe remaining solid partitioned between 10% KHSO4 and chloroform
3. washThe organic layer was washed with brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated to pure product by HPLC/MS and NMR