反应详情

To a solution of 2-amino-4-(isopropylsulfonyl)-1-(N-2-pyrrolidine-1-ylethylamino)benzene (122.9 mg, 0.39 mmol) in ethyl acetate (8 mL) was added tert-butylacetyl chloride (60 μL, 0.43 mmol) at room temperature, and the mixture was stirred for 1 h at room temperature. 2N—NaOH (1 mL) and ethanol (3 mL) were then added to the reaction mixture at room temperature, and stirred for 6 h at 80° C. The reaction was quenched with water, and extracted with three times with ethyl acetate. The combined organic layers were dried over MgSO4 and filtered. The filtrate was evaporated under reduced pressure. The residue was purified by amine coated silica gel column chromatography (hexane:ethyl acetate=3:1) to give the title compound as an orange solid (107.9 mg, 70%).

1. stirringstirred for 6 h at 80° C
2. customThe reaction was quenched with water
3. extractionextracted with three times with ethyl acetate
4. dry with materialThe combined organic layers were dried over MgSO4
5. filtrationfiltered
6. customThe filtrate was evaporated under reduced pressure
7. customThe residue was purified by amine coated silica gel column chromatography (hexane:ethyl acetate=3:1)