反应详情

1-(3-bromo-1-methylpropyl)-3-(2-fluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (0.1 g, 0.25 mmol) was dissolved in dimethylformamide (2 mL) in a microwave cuvette and potassium phthalimide (0.06 g, 0.3 mmol) was added. The mixture was irradiated at 100° C. for 3 minutes. Upon cooling the mixture was diluted with EtOAc and washed with water and brine then dried with Na2SO4. Upon concentration, the residue was dissolved in MeOH (5 mL), methyl hydrazine (0.06 g, 1.25 mmol) was added and the mixture heated to reflux for 5 hours. Upon cooling the reaction was concentrated and water (10 ml) added followed by acetic acid (to pH 4). After 1 hour the mixture was filtered and basified to pH 14 with NaOH then extracted with dichloromethane. The organic extracts were washed with water, dried with Na2SO4 and purified via Isco chromatography (Redisep, silica, gradient 0-10% 7M ammonia/MeOH solution in dichloromethane) to afford 32 mg of 3-[3-(2-fluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-N-methylbutan-1-amine.

1. additionwas added
2. customThe mixture was irradiated at 100° C. for 3 minutes
3. temperatureUpon cooling the mixture
4. washwashed with water and brine
5. dry with materialthen dried with Na2SO4
6. concentrationUpon concentration
7. dissolutionthe residue was dissolved in MeOH (5 mL)
8. temperaturethe mixture heated
9. temperatureto reflux for 5 hours
10. temperatureUpon cooling the reaction
11. concentrationwas concentrated
12. additionwater (10 ml) added
13. filtrationAfter 1 hour the mixture was filtered
14. extractionthen extracted with dichloromethane
15. washThe organic extracts were washed with water
16. dry with materialdried with Na2SO4
17. custompurified via Isco chromatography (Redisep, silica, gradient 0-10% 7M ammonia/MeOH solution in dichloromethane)