5-Methoxyindoleacetic acid → HCID 178488080, 화합물

HRID 1819695노트

반응식

HRID 1819695 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][C:10]([NH2:26])=[N:11][C:12](=[O:25])[CH2:13][C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH3:24])[CH:21]=3)[NH:16][CH:15]=2)[CH:5]=[C:4]([Cl:27])[C:3]=1[NH:28]C(=O)C.COC1C=C2C(=CC=1)NC=C2CC(O)=O.ClC1C=C(C=C(Cl)C=1N)CN>>[NH2:28][C:3]1[C:4]([Cl:27])=[CH:5][C:6]([CH2:8][NH:9][C:10]([NH2:26])=[N:11][C:12](=[O:25])[CH2:13][C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH3:24])[CH:21]=3)[NH:16][CH:15]=2)=[CH:7][C:2]=1[Cl:1]

참가 물질

4

반응물 3

HCID 189865-Methoxyindoleacetic acidHCID 189757634-Amino-3,5-dichlorobenzylamineHCID 178488081HCID 178488081, 화합물

생성물 1

HCID 178488080HCID 178488080, 화합물

실험 절차

In a manner similar to that used in the preparation of the compound of example 2, but using 2-(5-methoxy-1H-indol-3-yl)acetic acid in step 7 (A) and 3,5-dichloro-4-aminobenzylamine (preparation A) in step 7 (B), the title compound was prepared. MS (ESI) (M+H)+=419.99 1H-NMR (500 MHz, CD3OD) δ 7.29 (d, J=8.85 Hz, 1 H), 7.25 (s, 1 H), 7.21 (s, 2 H), 7.03 (d, J=2.44 Hz, 1 H), 6.82 (dd, J=8.85, 2.44 Hz, 1 H), 4.33 (s, 2 H), 3.92 (s, 2 H), 3.82 (s, 3 H).

출처 및 근거

ORD 기록
ord-e5bfce611fff47bfa58b3156d714c98a
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07601751B2

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