5-Methoxy-2-methylindole-3-acetic acid → HCID 178488074, 화합물

HRID 1819698노트

반응식

HRID 1819698 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][C:10]([NH2:26])=[N:11][C:12](=[O:25])[CH2:13][C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH3:24])[CH:21]=3)[NH:16][CH:15]=2)[CH:5]=[C:4]([Cl:27])[C:3]=1[NH:28][C:29](=[O:31])[CH3:30].[CH3:32]OC1C=C2C(=CC=1)NC(C)=C2CC(O)=O.C(NC1C(Cl)=CC(CN)=CC=1Cl)(=O)C>>[Cl:27][C:4]1[CH:5]=[C:6]([CH2:8][NH:9][C:10]([NH2:26])=[N:11][C:12](=[O:25])[CH2:13][C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH3:24])[CH:21]=3)[NH:16][C:15]=2[CH3:32])[CH:7]=[C:2]([Cl:1])[C:3]=1[NH:28][C:29](=[O:31])[CH3:30]

참가 물질

4

반응물 3

HCID 761515-Methoxy-2-methylindole-3-acetic acidHCID 58962993N-(4-(aminomethyl)-2,6-dichlorophenyl)acetamideHCID 178488081HCID 178488081, 화합물

생성물 1

HCID 178488074HCID 178488074, 화합물

실험 절차

In a manner similar to that used in the preparation of the compound of example 2, but using 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetic acid in step 10 (A) and 4-acetamido-3,5-dichloro-benzylamine (preparation B) in step 10 (B), the title compound was prepared. MS (ESI) (M+H)+=476.05 1H-NMR (300 MHz, CD3OD) δ 7.42 (s, 2 H), 7.18 (d, J=8.42 Hz, 1 H), 6.96 (d, J=2.56 Hz, 1 H), 6.64-6.84 (m, J=2.56 Hz, 1 H), 4.48 (s, 2 H), 3.88 (s, 2 H), 3.80 (s, 3 H), 2.40 (s, 3 H), 2.19 (s, 3 H).

출처 및 근거

ORD 기록
ord-9c643a78b2e64340a3082128913b70c7
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07601751B2

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