HCID 57887237, compound → HCID 178474304, compound

HRID 1819710Notes

Reaction equation

BrC1C=C2C(C(CC([N:14]=[C:15]([NH2:30])[NH:16][CH2:17][C:18]3[CH:23]=[C:22]([Cl:24])[C:21]([NH:25][C:26](=[O:28])[CH3:27])=[C:20]([Cl:29])[CH:19]=3)=O)=CN2)=CC=1.[Br:31][C:32]1[CH:33]=[C:34]2[C:38](=[CH:39][CH:40]=1)[NH:37][C:36]([C:41](=O)[NH:42]C(C)(C)C)=[C:35]2[CH2:48][C:49]([OH:51])=O>>[Br:31][C:32]1[CH:33]=[C:34]2[C:38](=[CH:39][CH:40]=1)[NH:37][C:36]([C:41]#[N:42])=[C:35]2[CH2:48][C:49]([N:14]=[C:15]([NH2:30])[NH:16][CH2:17][C:18]1[CH:19]=[C:20]([Cl:29])[C:21]([NH:25][C:26](=[O:28])[CH3:27])=[C:22]([Cl:24])[CH:23]=1)=[O:51]

Participants

Reactant 2

HCID 57887237HCID 57887237, compound

HCID 178474305HCID 178474305, compound

Product 1

HCID 178474304HCID 178474304, compound

Procedure

In a manner similar to that used in the preparation of the compound of example 1, but using 2-(5-bromo-2-(tert-butylcarbamoyl)-1H-indol-3-yl)acetic acid (preparation J) in step 25 (A), the title compound was prepared. 1H-NMR (500 MHz, CD3OD) δ ppm 2.19 (d, J=12.82 Hz, 3 H) 3.79 (s, 2 H) 4.31 (s, 2 H) 7.00 (s, 1 H) 7.26 (s, 1 H) 7.35 (d, J=8.24 Hz, 1 H) 7.85 (s, 1 H).

Sources & evidence

ORD record: ord-875af5278b6d4594a9b07b66ca8493cd
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07601751B2

Reaction notes

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