反应详情

Methyl 5-[(2-{[(5-chloropyridin-2-yl)amino]-carbonyl}benzofuran-3-yl)amino]-5-oxopentanoate (4.44 g) obtained in Example 9(1) is suspended in methanol (50 ml), and thereto is added 2N aqueous sodium hydroxide solution (30 ml) under ice-cooling followed by stirring at room temperature for 2 hours. After evaporating methanol under reduced pressure, the residue is diluted with water and washed with diethyl ether. The separated aqueous layer is acidified with 10% hydrochloric acid under ice-cooling, and the precipitates are collected by filtration. The resulting solid materials are washed successively with water, ethanol and diethyl ether, and dried to give the title compound (3.99 g). ESI-MS M/Z:400/402[M−H]−

1. temperaturecooling
2. customAfter evaporating methanol under reduced pressure
3. additionthe residue is diluted with water
4. washwashed with diethyl ether
5. temperaturecooling
6. filtrationthe precipitates are collected by filtration
7. washThe resulting solid materials are washed successively with water, ethanol and diethyl ether
8. customdried