反应详情

Phenyl[1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl]methanone (Reference Example 13) (2.2 g, 6.1 mmol) and 10% aq NaOH (70 mL) in EtOH (135 mL) was heated to reflux. After 14 h, the mixture was concentrated under reduced pressure to remove most of the EtOH. The mixture was diluted with H2O (50 mL) and extracted with EtOAc (2×100 mL). The combined extracts were washed with saturated NaCl (25 mL), dried (Na2SO4) and concentrated under reduced pressure. Trituration in EtOAc/diethyl ether gave phenyl(1H-pyrrolo[2,3-c]pyridin-2-yl)methanone (1.14 g, 83%).

1. concentrationthe mixture was concentrated under reduced pressure
2. customto remove most of the EtOH
3. additionThe mixture was diluted with H2O (50 mL)
4. extractionextracted with EtOAc (2×100 mL)
5. washThe combined extracts were washed with saturated NaCl (25 mL)
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated under reduced pressure