反应详情

Phenyl (1H-pyrrolo[2,3-c]pyridin-2-yl)methanone O-pyrrolidin-3-yloxime dihydrochloride (12.3 mg, 33%) was prepared as an off-white amorphous solid from tert-butyl 3-[[[phenyl (1H-pyrrolo[2,3-c]pyridin-2-yl)methylene]amino]oxy]pyrrolidine-1-carboxylate (Example 90) following the procedure described for Example 77, except 1:1 trifluoroacetic acid/CH2Cl2 was used: 1H NMR (500 MHz, CD3OD) major isomer δ 0.94-0.92 (1H, m), 2.33-2.35 (1H, m), 3.26-3.27 (1H, m), 3.33-3.34 (1H, m), 3.45-3.46 (1H, m), 3.58-3.60 (1H, m), 3.70-3.72 (1H, m), 5.23-5.24 (1H, m), 6.78 (1H, s), 7.53-7.57 (5H, m), 8.08 (1H, d, J=6.4 Hz), 8.22 (1H, d, J=6.5 Hz), 9.01 (1H, s); ESI MS m/z 307 [C18H18N4O+H]+; HPLC (Method A) 96.6% (AUC), tR=12.6 min.