3-[4-(5-Bromo-2-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester → 3-{4-[5-(4-Ethyl-2-phenoxy-phenoxy)-2-fluoro-phenoxy]-2-methyl-phenyl}-propionic acid

HRID 1822255Notes

Reaction equation

HRID 1822255 reaction equation
C[O:2][C:3](=[O:22])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[C:17](Br)[CH:16]=[CH:15][C:14]=2[F:20])=[CH:8][C:7]=1[CH3:21].[CH2:23]([C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:26]=1)[CH3:24]>>[CH2:23]([C:25]1[CH:30]=[CH:29][C:28]([O:31][C:17]2[CH:16]=[CH:15][C:14]([F:20])=[C:13]([CH:18]=2)[O:12][C:9]2[CH:10]=[CH:11][C:6]([CH2:5][CH2:4][C:3]([OH:2])=[O:22])=[C:7]([CH3:21])[CH:8]=2)=[C:27]([O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:26]=1)[CH3:24]

Participants

3

Reactant 2

HCID 578941283-[4-(5-Bromo-2-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl esterHCID 587537954-Ethyl-2-phenoxy-phenol

Product 1

HCID 578941633-{4-[5-(4-Ethyl-2-phenoxy-phenoxy)-2-fluoro-phenoxy]-2-methyl-phenyl}-propionic acid

Procedure

The title compound is prepared according to Example 13, Step C by using 3-[4-(5-bromo-2-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester and 4-ethyl-2-phenoxy-phenol to afford 15 mg (11%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C30H27FO5 486, found 487 (M+1, 100%).

Workup

  1. customto afford 15 mg (11%)

Sources & evidence

ORD record
ord-dfe232e05c0b4561aac505b8171b444d
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

Loading…