Methyl({2-[(tert-butoxycarbonyl)amino]butanoyl}amino)(cyclopropyl)acetate → Methyl[(2-aminobutanoyl)amino](cyclopropyl)acetate hydrochloride

HRID 1824236Notes

Reaction equation

HRID 1824236 reaction equation
[ClH:1].COC(=O)C(NC(=O)[C@H](C)N)C1CC1.[CH3:16][O:17][C:18](=[O:37])[CH:19]([NH:23][C:24](=[O:36])[CH:25]([NH:28]C(OC(C)(C)C)=O)[CH2:26][CH3:27])[CH:20]1[CH2:22][CH2:21]1>>[ClH:1].[CH3:16][O:17][C:18](=[O:37])[CH:19]([NH:23][C:24](=[O:36])[CH:25]([NH2:28])[CH2:26][CH3:27])[CH:20]1[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 23593721Methyl({2-[(tert-butoxycarbonyl)amino]butanoyl}amino)(cyclopropyl)acetateHCID 86588880methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride

Product 1

HCID 86588881Methyl[(2-aminobutanoyl)amino](cyclopropyl)acetate hydrochloride

Procedure

Following the procedure for the preparation of methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride but substituting methyl({2-[(tert-butoxycarbonyl)amino]butanoyl}amino)(cyclopropyl)acetate and making non-critical variations provided the title compound as a solid: 1H NMR (DMSO-d6) δ 0.29–0.40, 0.88–0.94, 1.12, 1.37, 1.75–1.82, 3.57, 3.62–3.79, 8.29.

Sources & evidence

ORD record
ord-b9d63075769048ae8ebbbb4233055ec8
Source dataset
uspto-grants-2006_05
Patent number
US07041672B2

Reaction notes

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