反应详情

This material was prepared by the hydrolysis of methyl 6-[(2-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}thieno[3,2-b]pyridin-7-yl)oxy]-2-methylbenzo[b]thiophene-3-carboxylate 122a (63 mg, 0.13 mmole) with LiOH.H2O (54 mg, 13 mmole) in a manner as previously described for example 11c to give a white solid (46 mg, 75%). 1H NMR (DMSO-d6, 300 MHz) δ 8.58 (1H, d, J=5.46 Hz), 8.44 (1H, d, J=8.85 Hz), 8.03 (1H, s), 8.00 (1H, d, J=2.26 Hz), 7.38 (1H, dd, J=2.45, 9.04 Hz), 6.78 (1H, d, J=5.84 Hz), 4.35–4.25 (1H, m), 3.93–3.76 (2 H, m), 3.59–3.50 (2H, m), 3.27, 3.15 (3H, s), 2.81 (3H, s), 2.11–1.83 (4H, m).