反应详情

A reaction mixture of 3-[1-(3,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1-(imidazole-1-ylcarbonyl)-1,3-dihydro-indol-2-one (5.3 mg, 0.016 mmol) in 1.0 mL of methanol was stirred at room temperature for 64 h and filtered. The red solid was washed with methanol and dried in a vacuum oven overnight to afford 3-[1-(3,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-indole-1-carboxylic acid methyl ester (3.0 mg, 63%) as a red solid. 1H NMR (400 MHz, DMSO-d6) d 12.63 (s, 1H, NH-1′), 7.84–7.86 (m, 1H), 7.69 (s, 1H, H-vinyl), 7.56–7.68 (m, 1H), 7.19–7.22 (m, 2H), 6.06 (d, J=2.34 Hz, 1H, H-4′), 4.08 (s, 3H, OCH3), 2.40 (s, 3H, CH3), and 2.36 (s, 3H, CH3). MS m/z (relative intensity, %) 297 (100, [M+1]+.)

1. filtrationfiltered
2. washThe red solid was washed with methanol
3. customdried in a vacuum oven overnight