HCID 22136558, compound → HCID 10367092, compound

HRID 1827491Notes

Reaction equation

HRID 1827491 reaction equation
C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[N:16]=[C:15]([CH:20]=[CH:21][C:22]2[C:30]3[C:25](=[CH:26][C:27]([NH:31][C:32]4[N:40]=[CH:39][CH:38]=[CH:37][C:33]=4[C:34](O)=[O:35])=[CH:28][CH:29]=3)[NH:24][N:23]=2)[CH:14]=1.[CH:41]1([C:44]#[C:45][CH2:46][NH2:47])[CH2:43][CH2:42]1>>[CH:41]1([C:44]#[C:45][CH2:46][NH:47][C:34](=[O:35])[C:33]2[CH:37]=[CH:38][CH:39]=[N:40][C:32]=2[NH:31][C:27]2[CH:26]=[C:25]3[C:30]([C:22](/[CH:21]=[CH:20]/[C:15]4[CH:14]=[C:13]([CH3:12])[CH:18]=[C:17]([CH3:19])[N:16]=4)=[N:23][NH:24]3)=[CH:29][CH:28]=2)[CH2:43][CH2:42]1

Participants

3

Reactant 2

HCID 22136558HCID 22136558, compoundHCID 86594462HCID 86594462, compound

Product 1

HCID 10367092HCID 10367092, compound

Procedure

Prepared-in a similar manner to that described for Example 6 above, except using 2-{3-[2-(4,6-Dimethyl-pyridin-2-yl)-vinyl]-1H-indazol-6-ylamino}-nicotinic acid p-toluene sulfonate and 3-Cyclopropyl-prop-2-ynylamine. 1H NMR (DMSO-d6): δ 13.01 (1H, s), 11.20 (1H, s), 9.19 (1H, bt), 8.51 (1H, s), 8.40 (1H, d, J=4.9 Hz), 8.15 (1H, d, J=7.5 Hz), 8.05 (1H, d, J=8.7 Hz), 7.83 (1H, d, J=16.4 Hz), 7.42 (1H, d, J=16.4 Hz), 7.31 (1H, s), 7.05 (1H, d, J=8.3 Hz), 6.96 (1H, s), 6.92 (1H, dd, J=7.5, 4.9 Hz), 4.06 (2H, d, J=4.14 Hz), 2.46 (3H, s), 2.29 (3H, s), 1.33–1.28 (1H, m), 0.77–0.72 (2H, m), 0.60–0.55 (2H, m).

Sources & evidence

ORD record
ord-15837ca26eb64b629990c691c209d247
Source dataset
uspto-grants-2006_05
Patent number
US07053107B2

Reaction notes

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