2-Methylallylamine → HCID 69353414, compound

HRID 1827493Notes

Reaction equation

HRID 1827493 reaction equation
[CH3:1][C:2](=[CH2:5])[CH2:3][NH2:4].[CH3:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([CH:13]=[CH:14][C:15]2[C:23]3[C:18](=[CH:19][C:20]([NH:24][C:25]4[CH:33]=[CH:32][CH:31]=[CH:30][C:26]=4[C:27](O)=[O:28])=[CH:21][CH:22]=3)[N:17]([CH:34]3[CH2:39][CH2:38][CH2:37][CH2:36][O:35]3)[N:16]=2)[CH:8]=1>CC(OC)(C)C>[CH3:5][C:2](=[CH2:1])[CH2:3][NH:4][C:27](=[O:28])[C:26]1[CH:30]=[CH:31][CH:32]=[CH:33][C:25]=1[NH:24][C:20]1[CH:19]=[C:18]2[C:23]([C:15]([CH:14]=[CH:13][C:9]3[CH:8]=[C:7]([CH3:6])[CH:12]=[CH:11][N:10]=3)=[N:16][N:17]2[CH:34]2[CH2:39][CH2:38][CH2:37][CH2:36][O:35]2)=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 761412-MethylallylamineHCID 693525322-[3-[2-(4-Methyl-pyridin-2-yl)-vinyl]-1-(tetrahydro-pyran-2-yl)-1H-indazol-6-ylamino]-benzoic acid

Product 1

HCID 69353414HCID 69353414, compound

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

Prepared in a similar manner to that described for Example 6 above, except using 2-Methyl-allylamine and 2-[3-[2-(4-Methyl-pyridin-2-yl)-vinyl]-1-(tetrahydro-pyran-2-yl)-1H-indazol-6-ylamino]-benzoic acid. 1H NMR (DMSO-d6) δ 9.86 (1H, s), 8.81 (1H, t, J=5.5 Hz), 8.46 (1H, d, J=4.9 Hz), 8.07 (1H, d, J=8.9 Hz), 7.86 (1H, d, J=16.4 Hz), 7.75 (1H, d, J=7.7 Hz), 7.54 (1H, s),7.50 (1H, d, J=16.4 Hz), 7.43 (3H, m), 7.11 (2H, m), 6.92 (1H, t, J=8.1 Hz), 5.81 (1H, dd, J=2.5, 9.8 Hz), 4.83 (2H, d, J=11.5 Hz), 3.81 (4H, m), 2.41 (1H, m), 2.35 (3H, s), 2.00 (2H, m), 1.76 (1H, m), 1.73 (3H, s), 1.58 (2H, m). Anal. Calcd for C31H33N5O2.0.80 TBME: C, 72.71; H, 7.43; N, 12.11. Found: C, 72.43; H, 7.57; N, 12.02.

Workup

  1. customPrepared in a similar manner to that

Sources & evidence

ORD record
ord-43a97c34bb9843288a3ed3bb40b69963
Source dataset
uspto-grants-2006_05
Patent number
US07053107B2

Reaction notes

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