反应详情

To a solution of 4-bromo-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-N-[3-(tetrahydro-pyran-2-yloxy)-benzyl]-2-trifluoromethoxy-benzenesulfonamide (0.106 g, 0.15 mmol) in 4 mL ethanol was added 0.8 mL of 1.2N HCl. The reaction mixture was stirred at room temperature for 6 days and was diluted with 10 mL saturated aqueous sodium bicarbonate. The aqueous solution was washed with methylene chloride (2×10 mL). The combined organic layers were dried (sodium sulfate), filtered, and concentrated in vacuo. The residue was purified by preparative TLC (1.0 mm silica gel layer, eluting with 10% methanol/ethyl acetate) to afford 0.030 g (29%) of 4-bromo-N-(3-hydroxy-benzyl)-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-2-trifluoromethoxy-benzenesulfonamide. MS 617.3 (M+1)+

1. washThe aqueous solution was washed with methylene chloride (2×10 mL)
2. dry with materialThe combined organic layers were dried (sodium sulfate)
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customThe residue was purified by preparative TLC (1.0 mm silica gel layer, eluting with 10% methanol/ethyl acetate)