Hydrochloric Acid → HCID 86589983, compound

HRID 1829840Notes

Reaction equation

C([O:5][C:6](=[O:17])[CH2:7][CH:8]([NH2:16])[CH2:9][C:10]([CH3:15])([CH3:14])[CH2:11][CH2:12][CH3:13])(C)(C)C.[ClH:18]>>[ClH:18].[NH2:16][C@@H:8]([CH2:9][C:10]([CH3:14])([CH3:15])[CH2:11][CH2:12][CH3:13])[CH2:7][C:6]([OH:17])=[O:5]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 85871156HCID 85871156, compound

Product 1

HCID 86589983HCID 86589983, compound

Procedure

According to example 1, 3-amino-5,5-dimethyl-octanoic acid tert-butyl ester was treated with 3N HCl to provide 286 mg of the title compound as a solid. 1HNMR (400 MHz; CD3OD): 0.87–0.93 (m, 9H), 1.18–1.31 (m, 4H), 1.51 (dd, 1H, J=4 Hz, 14.4 Hz), 1.62 (dd, 1H, J=6.8 Hz, 14.4 Hz), 2.60 (dd, 1H, J=8 Hz, 17.6 Hz), 2.73 (dd, 1H, J=4 Hz, 7.6 Hz), 3.55–3.60 (m, 1H). MS (APCI), m/z: 188.1 (M+1)+. 186.1 (M−1)+. Anal. Calc'd for C10H21NO2.HCl.0.12H2O: C: 53.17, H: 9.92, N: 6.20, Cl: 15.69; Found: C: 53.19, H: 10.00, N: 6.08, Cl: 15.25. α=+20° (MeOH). MP: 194.2–195.2° C.

Sources & evidence

ORD record: ord-1b364bc079694239b826547da2559806
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07064147B2

Reaction notes

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