反应详情

To a stirred solution of 2.64 g of N-butylglycine tert-butyl ester in 20 ml of chloroform was carefully added N2 -(6,7-dimethoxy-2-naphthylsulfonyl)-L-arginyl chloride obtained above. The reaction mixture was allowed to stand at room temperature for 1 hour. At the end of this period, the reaction mixture was washed twice with 20 ml of saturated sodium chloride solution and evaporated to dryness. The residue was triturated with a small amount of water to give a crystalline material. This was collected by filtration and recrystallized from ethanol-ethyl ether to give 2.28 g (82 percent) of N2 -(6,7-dimethoxy-2-naphthylsulfonyl)-L-arginyl-N-butylglycine tert-butyl ester, M.P. 164-166° C, I.R. (KBr): 3,390, 3,165, 1,735, 1,370 cm-1.

1. customobtained above
2. washAt the end of this period, the reaction mixture was washed twice with 20 ml of saturated sodium chloride solution
3. customevaporated to dryness
4. customThe residue was triturated with a small amount of water
5. customto give a crystalline material
6. filtrationThis was collected by filtration
7. customrecrystallized from ethanol-ethyl ether