反应详情

Undistilled ethyl 5-cyano-4-oxo-5-(2-methylphenyl)pentanoate (prepared by the procedure described above; 773 g.) was heated under reflux with hydrobromic acid (48-50%; 1550 ml.) for 3 hours. On cooling, the reaction mixture separated into two layers. The lower, aqueous phase was separated and extracted with chloroform (3 × 500 ml.). The chloroform extract was added to the upper, organic layer of the reaction mixture. The chloroform solution (about 2 liters) thus obtained was washed with water (3 × 200 ml.) and evaporated to give 5-(2-methylphenyl)-4-oxopentanoic acid (535 g.) in the form of a dark coloured oil.

1. temperature) was heated
2. temperatureOn cooling
3. customthe reaction mixture separated into two layers
4. customThe lower, aqueous phase was separated
5. extractionextracted with chloroform (3 × 500 ml.)
6. extractionThe chloroform extract
7. additionwas added to the upper, organic layer of the reaction mixture
8. customThe chloroform solution (about 2 liters) thus obtained
9. washwas washed with water (3 × 200 ml.)
10. customevaporated