Sodium Hydroxide → HCID 13696092, compound

20 g (0.1 mol)of ethyl 4-vinylphenylpropionate was fed to a 1-liter three-necked flask, 100 ml of THF was added and well dissolved, and further 0.3 g of 2,4,6-tris(3′,5′-di-t-butyl-4′-hydroxybenzyl)mesitylene was added. 100 ml of a 1.5 N aqueous solution of sodium hydroxide was added dropwise under stirring at room temperature and stirred at 50° C. for 1.5 hours. After THF was distilled off under reduced pressure and the reaction product was extracted with 100 ml of n-hexane twice, 15 ml of 37% concentrated hydrochloric acid was added dropwise under stirring to produce a white precipitate. The precipitate was separated by filtration, washed in cold water completely and vacuum dried at 50° C. for 12 hours to obtain 12 g of 4-vinylphenylpropionic acid (C11H12O2). The yield was 68%. According to elemental analysis (wt %), C: 74.76 (calculated value: 74.98) and H: 6.91 (calculated value: 6.86). FIG. 3 shows a nuclear magnetic resonance spectrum of this compound and FIG. 4 shows an infrared absorption spectrum of this compound.

1. dissolutionwell dissolved
2. stirringstirred at 50° C. for 1.5 hours
3. distillationAfter THF was distilled off under reduced pressure
4. extractionthe reaction product was extracted with 100 ml of n-hexane twice
5. addition15 ml of 37% concentrated hydrochloric acid was added dropwise
6. stirringunder stirring
7. customto produce a white precipitate
8. customThe precipitate was separated by filtration
9. washwashed in cold water completely
10. customvacuum dried at 50° C. for 12 hours

ORD record

ord-9d1070e150bf4fb5a1b08b09b85540c2

Source dataset

uspto-grants-2004_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06770780B1