反应详情

To a stirred solution of 2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (0.50 g, 1.31 mmol) in MeCN (10 ml) was added cyclohexylamine (0.50 ml) and the resultant solution heated under reflux for 26 h. The cooled reaction mixture was concentrated in vacuo and the residue partitioned between 2N HCl and ethyl acetate. The organic phase was separated, washed with 2N HCl then water and concentrated in vacuo to an off-white solid. This solid was crystalised from 5% AcOH/MeOH and dried in vacuo to give the title compound as a white solid (0.27 g, 52%).

1. temperatureunder reflux for 26 h
2. customThe cooled reaction mixture
3. concentrationwas concentrated in vacuo
4. customthe residue partitioned between 2N HCl and ethyl acetate
5. customThe organic phase was separated
6. washwashed with 2N HCl
7. concentrationwater and concentrated in vacuo to an off-white solid
8. customThis solid was crystalised from 5% AcOH/MeOH
9. customdried in vacuo