反应详情

Following the procedure of Reference Example 32, 7-(2-methoxyethoxy)-4-oxo-1,4-dihydroquinoline-3-carbonitrile (800 mg, 3.28 mmol), thionyl chloride and a catalytic amount of N,N-dimethylformamide provides 748 mg of 4-chloro-7-(2-methoxyethoxy)quinoline-3-carbonitrile as an off-white solid solid, mp 143-145° C.