反应详情

Following the procedure used to prepare Example 15, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-fluoro-3-quinolinecarbonitrile (250 mg, 0.64 mmol) and tetrahydropyran-2-methanol provides 177 mg of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(tetrahydro-2H-pyran-2-ylmethoxy)-3-quinolinecarbonitrile, mp 193-196° C.