Tetrahydropyran-2-methanol → 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(tetrahydro-2H-pyran-2-ylmethoxy)-3-quinolinecarbonitrile

HRID 1837369노트

반응식

HRID 1837369 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[NH:11][C:12]1[C:21]2[C:16](=[CH:17][C:18](F)=[C:19]([O:22][CH2:23]C)[CH:20]=2)[N:15]=[CH:14][C:13]=1[C:26]#[N:27].[O:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH:29]1[CH2:34][OH:35]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[NH:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:35][CH2:34][CH:29]3[CH2:30][CH2:31][CH2:32][CH2:33][O:28]3)=[C:19]([O:22][CH3:23])[CH:20]=2)[N:27]=[CH:26][C:13]=1[C:14]#[N:15]

참가 물질

3

반응물 2

HCID 7524Tetrahydropyran-2-methanolHCID 115459364-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-fluoro-3-quinolinecarbonitrile

생성물 1

HCID 103453764-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(tetrahydro-2H-pyran-2-ylmethoxy)-3-quinolinecarbonitrile

실험 절차

Following the procedure used to prepare Example 15, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-fluoro-3-quinolinecarbonitrile (250 mg, 0.64 mmol) and tetrahydropyran-2-methanol provides 177 mg of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(tetrahydro-2H-pyran-2-ylmethoxy)-3-quinolinecarbonitrile, mp 193-196° C.

출처 및 근거

ORD 기록
ord-247db63a68684f16a6ec1ea72c5937f0
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06780996B2

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