Hydrochloric Acid → HCID 21973956, compound

HRID 18402Notes

Reaction equation

HRID 18402 reaction equation
[C:1]12([CH2:11][CH2:12][N:13]([CH2:26][CH2:27][N:28](C(OC(C)(C)C)=O)[CH3:29])[C:14]([NH:16][CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)=[O:15])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[ClH:37]>CO>[ClH:37].[ClH:37].[C:1]12([CH2:11][CH2:12][N:13]([CH2:26][CH2:27][NH:28][CH3:29])[C:14]([NH:16][CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)=[O:15])[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH2:2]1)[CH2:10]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10228693HCID 10228693, compound

Product 1

HCID 21973956HCID 21973956, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Methanol (4.4 ml) was added to 1-[2-(1-adamantyl)ethyl]-1-[2-[N-(t-butoxycarbonyl)-N-methylamino]ethyl]-3-[3-(4-pyridyl)propyl]urea (Compound No. 1-26, 0.30 g, 0.60 mmol), and the mixture was stirred at room temperature in a vessel equipped with a calcium chloride tube. A 10% solution of hydrogen chloride in methanol (4.4 ml) was added to the mixture, and the whole was stirred for one day and then concentrated under reduced pressure to give the target compound (0.30 g, quantitatively) as pale yellow amorphous powder.

Workup

  1. customequipped with a calcium chloride tube
  2. stirringthe whole was stirred for one day
  3. concentrationconcentrated under reduced pressure
  4. customto give the target compound (0.30 g

Sources & evidence

ORD record
ord-72ca5a31fa3941eebd6a4fdb3725964b
Source dataset
uspto-grants-2010_06
Patent number
US07741346B2

Reaction notes

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