HCID 10958012, compound → HCID 23447870, compound

HRID 1840302Notes

Reaction equation

HRID 1840302 reaction equation
Cl[CH2:2][CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:10][O:11][C:12]=1[CH3:13])=[O:7].[F:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[C:23]([O:33][CH2:34][C:35]([F:38])([F:37])[F:36])[CH:22]=1.O[C:40]1C=CC(Cl)=CC=1N1CCNCC1>C(OCC)(=O)C>[CH2:13]([C:12]1[O:11][N:10]=[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]=1[C:6]([NH:5][CH2:4][CH2:3][CH2:2][N:30]1[CH2:31][CH2:32][N:27]([C:24]2[CH:25]=[CH:26][C:21]([F:20])=[CH:22][C:23]=2[O:33][CH2:34][C:35]([F:37])([F:36])[F:38])[CH2:28][CH2:29]1)=[O:7])[CH3:40]

Participants

5

Reactant 3

HCID 10958012HCID 10958012, compoundHCID 23447862HCID 23447862, compoundHCID 234478814-Chloro-2-(1-piperazinyl)phenol

Product 1

HCID 23447870HCID 23447870, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was obtained following the procedure described in Example 2 but substituting Compound 19A for Compound 2B and 1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazine for 1-(2-hydroxy-5-chlorophenyl)piperazine. The crude was taken up with ethyl acetate and the crude was purified by flash chromatography (ethyl acetate-2 N ammonia in methanol 98:2) to afford the title compound (64%). M.p. 115-117° C.

Workup

  1. customthe crude was purified by flash chromatography (ethyl acetate-2 N ammonia in methanol 98:2)

Sources & evidence

ORD record
ord-0b67aa42751b488796cdea982178a760
Source dataset
uspto-grants-2004_01
Patent number
US06680319B2

Reaction notes

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