HRID1840624

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2733826

未命名化合物

结构：CC(C)C[C@@H](C(=O)O)N1C(=O)NC(C(F)(F)F)(C(F)(F)F)C1=O

HCID9924523

未命名化合物

HCID11162525

未命名化合物

PRODUCTS

生成物

结构：COc1cc(CN2C(=O)N([C@@H](CC(C)C)C(=O)N[C@H](C)CC(=O)O)C(=O)C2(C(F)(F)F)C(F)(F)F)ccc1NC(=O)Nc1ccccc1C

HCID12044603

未命名化合物

收率 53%

PROCEDURE

实验过程

which had been prepared from (S)-2-(4,4-bis(trifluoromethyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetic acid and 4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl chloride as described in Example 18f, and 128 mg (0.809 mmol) of tert-butyl (R)-3-aminobutanoate. After coupling, chromatographic purification over silica gel (eluent: heptane/ethyl acetate=3/2) and cleavage of the tert-butyl ester, 299 mg (53%) of the title compound were obtained.

WORKUP

后处理

customchromatographic purification over silica gel (eluent: heptane/ethyl acetate=3/2) and cleavage of the tert-butyl ester

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f074dd3d26e044e78e8ec478aca35356
来源数据集: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06680333B2
来源说明: uspto-grants-2004_01

反应 SMILES

[F:1][C:2]([F:23])([F:22])[C:3]1([C:18]([F:21])([F:20])[F:19])[C:7](=[O:8])[N:6]([C@@H:9]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:10](O)=[O:11])[C:5](=[O:17])[NH:4]1.[CH3:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[NH:31][C:32](=[O:44])[NH:33][C:34]1[CH:41]=[CH:40][C:37]([CH2:38]Cl)=[CH:36][C:35]=1[O:42][CH3:43].[NH2:45][C@H:46]([CH3:55])[CH2:47][C:48]([O:50]C(C)(C)C)=[O:49]>>[F:1][C:2]([F:22])([F:23])[C:3]1([C:18]([F:21])([F:20])[F:19])[C:7](=[O:8])[N:6]([C@@H:9]([CH2:13][CH:14]([CH3:15])[CH3:16])[C:10]([NH:45][C@H:46]([CH3:55])[CH2:47][C:48]([OH:50])=[O:49])=[O:11])[C:5](=[O:17])[N:4]1[CH2:38][C:37]1[CH:40]=[CH:41][C:34]([NH:33][C:32]([NH:31][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH3:24])=[O:44])=[C:35]([O:42][CH3:43])[CH:36]=1