反应详情

A 1.0M solution of lithium aluminium hydride in tetrahydrofuran (8 ml) was cooled to 0° C. in an ice/methanol bath with stirring under argon. The solution was then treated dropwise with a solution of N-[5-(3-cyanophenyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide (0.67 g, 1.97 mmol) in dry tetrahydrofuran (20 ml) over 15 mins. The cooling bath was removed and the whole mix stirred at reflux for 2 h. The reaction mix was allowed to cool to room temperature and quenched with water (0.8 ml), 10% NaOH (0.8 ml), and water again (1.2 ml). The reaction mix was dried over sodium sulphate, filtered and the filtrate evaporated under reduced pressure to give the title compound as a yellow oil (0.67 g, 100%).

1. customThe cooling bath was removed
2. additionthe whole mix
3. stirringstirred
4. temperatureat reflux for 2 h
5. additionThe reaction mix
6. customquenched with water (0.8 ml), 10% NaOH (0.8 ml), and water again (1.2 ml)
7. additionThe reaction mix
8. dry with materialwas dried over sodium sulphate
9. filtrationfiltered
10. customthe filtrate evaporated under reduced pressure