反应详情

To tert-butyl (3-((3-bromopyridin-2-yl)oxy)cyclobutyl)carbamate (see PREPARATION 7B; 342 mg, 1 mmol) was added 4 M HCl in MeOH (50 mL). The solution was stirred at RT for 2 hours. The solvent was removed under reduced pressure to give 3-((3-bromopyridin-2-yl)oxy)cyclobutanamine hydrochloride (223 mg, 0.95 mmol, yield 95%). ESI-MS (M+1): 243 calc. for C9H11BrN2O 242.

1. customThe solvent was removed under reduced pressure