反应详情

温度

30 °C

A mixture of tert-butyl 2-(3-(4-methylphenylsulfonamido)cyclobutoxy)-5′,6′-dihydro-[3,4′-bipyridine]-1′(2′H)-carboxylate (499 mg, 1 mmol) and wet Pd—C (50%, 1.0 g) in MeOH (50 mL) was stirred under H2 (40 psi) at 30° C. overnight then the reaction mixture was filtered through CELITE® and washed with MeOH. The filtrate was concentrated to give tert-butyl 4-(2-(3-(4-methylphenylsulfonamido)cyclobutoxy)pyridin-3-yl)piperidine-1-carboxylate (476 mg, 0.95 mmol, yield 95%). ESI-MS (M+1): 502 calc. for C26H35N3O5S 501.

1. filtrationthe reaction mixture was filtered through CELITE®
2. washwashed with MeOH
3. concentrationThe filtrate was concentrated