(2S)-2-Amino-1,1-diphenylpropan-1-ol → HCID 86706787, compound

Temperature

50 °C

(6-Hydroxy-1-benzofuran-3-yl)acetic acid (25 g), dichloro[(+)-1,2-bis((2R,5R)-2,5-diisopropylphosphorano)benzene]ruthenium (II)-N,N-dimethylformamide complex (19.1 mg) and (S)-2-amino-1,1-diphenylpropan-1-ol (29.5 g) were weighted in an autoclave and substituted with argon. Dehydrated methanol (250 mL) was added and the mixture was purged with hydrogen, pressurized under a hydrogen pressure (1.0 MPa), and reacted at 35° C. for 15 hr. The reaction mixture was concentrated under reduced pressure, methanol (109 mL) and N,N-dimethylformamide (27 mL) were added, and the mixture was dissolved by heating at 50° C. Isopropyl ether (200 mL) was added dropwise at 60° C., seed crystal was added, and isopropyl ether (369 mL) was added dropwise. The mixture was cooled to room temperature, stirred for 4 hr and stirred for 1 hr under ice-cooling, and the solid was collected by filtration. The solid was dried at 60° C. under reduced pressure to give the title compound (38.98 g). 99.8% de.

1. customthe mixture was purged with hydrogen
2. customreacted at 35° C. for 15 hr
3. concentrationThe reaction mixture was concentrated under reduced pressure, methanol (109 mL) and N,N-dimethylformamide (27 mL)
4. additionwere added
5. dissolutionthe mixture was dissolved
6. additionIsopropyl ether (200 mL) was added dropwise at 60° C.
7. additionseed crystal was added
8. additionisopropyl ether (369 mL) was added dropwise
9. temperatureThe mixture was cooled to room temperature
10. stirringstirred for 1 hr under ice-
11. temperaturecooling
12. filtrationthe solid was collected by filtration
13. customThe solid was dried at 60° C. under reduced pressure

ORD record

ord-769b96e918cb4f0496d8144527ee5207

Source dataset

uspto-grants-2015_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08952185B2