反应详情

温度

70 °C

To a solution of methyl(S)-2-(6-(((trifluoromethyl)sulfonyl)oxy)-2,3-dihydrobenzofuran-3-yl)acetate (4.88 g) and (2′,6′-dimethyl-4′-(3-(methylsulfonyl)propoxy)-[1,1′-biphenyl]-3-yl)methanol (5.00 g) in acetonitrile (15 mL) was added tripotassium phosphate (4.57 g), and the mixture was stirred at 70° C. for 3 hr. The mixture was allowed to cool to room temperature and concentrated, toluene (60 mL) and water (60 mL) were added, and an extraction operation was performed. The organic layer was washed with water (60 mL) and 10% brine (60 mL), and concentrated. The obtained oil was dissolved in dimethyl sulfoxide (30 mL), and 2N sodium hydroxide (8 mL) was added at room temperature. The mixture was stirred at 70° C. for 1 hr, and allowed to cool to room temperature. Ethyl acetate (60 mL) and water (60 mL) were added, and the mixture was partitioned. The aqueous layer was acidified with 6N hydrochloric acid to pH 1, ethyl acetate (60 mL) was added, and an extraction operation was performed. The organic layer was washed with water (60 mL), and concentrated. The crude product was recrystallized from acetone (30 mL)-water (60 mL), and the obtained solid was dried at 60° C. under reduced pressure to give the title compound (4.82 g) as white crystals. Yield 64%.

1. temperatureto cool to room temperature
2. concentrationconcentrated
3. additiontoluene (60 mL) and water (60 mL) were added
4. washThe organic layer was washed with water (60 mL) and 10% brine (60 mL)
5. concentrationconcentrated
6. dissolutionThe obtained oil was dissolved in dimethyl sulfoxide (30 mL)
7. addition2N sodium hydroxide (8 mL) was added at room temperature
8. stirringThe mixture was stirred at 70° C. for 1 hr
9. temperatureto cool to room temperature
10. additionEthyl acetate (60 mL) and water (60 mL) were added
11. customthe mixture was partitioned
12. additionwas added
13. washThe organic layer was washed with water (60 mL)
14. concentrationconcentrated
15. customThe crude product was recrystallized from acetone (30 mL)-water (60 mL)
16. customthe obtained solid was dried at 60° C. under reduced pressure