反应详情

温度

30 °C

Following the procedure for 376, 2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-8-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-azetidin-3-yl}-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene was reacted with MeOH as the solvent and the reaction mixture was warmed to 30° C. The crude product was triturated with diethyl ether to give 322 as a yellow solid (92 mg, quant.) LCMS: RT=3.03 min, [M+H]+=412. 1H NMR δ (ppm) (DMSO-d6): 10.65 (1 H, s), 8.34-8.25 (1 H, m), 8.06 (1 H, s), 7.27-7.20 (1H, m), 7.15 (1 H, dd, J=14.90, 1.71 Hz), 5.80-5.71 (1 H, m), 4.41-4.21 (5 H, m), 4.20-4.08 (1 H, m), 3.67-3.56 (2 H, m), 3.45-3.30 (2 H, m), 3.26 (1 H, dd, J=10.12, 5.06 Hz), 1.51-1.46 (6 H, m). 2 Protons obscured by water peak and 1 exchangeable not observed

1. customThe crude product was triturated with diethyl ether