反应详情

温度

80 °C

5-(4-Aminophenyl)-1,5,8,9,10,11-hexahydronaphtho[1,2-b][1,4]diazepine-2,4-dione (190 mg, 0.59 mmol) obtained in Example 10, o-nitrobenzenesulfonyl chloride (197 mg, 0.89 mmol), and dry pyridine (5 mL) were mixed. The mixture was stirred at 80° C. for 17 hours. Pyridine was removed by evaporation under reduced pressure. To the residue was added water. The mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with dilute hydrochloric acid, and dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure. The residue was purified by silica gel column chromatography (chloroform) to give the titled compound as pale yellow crystal (233 mg, yield 78%).

1. customPyridine was removed by evaporation under reduced pressure
2. additionTo the residue was added water
3. extractionThe mixture was extracted with ethyl acetate
4. washThe ethyl acetate layer was washed with dilute hydrochloric acid
5. dry with materialdried over anhydrous sodium sulfate
6. customThe solvent was removed by evaporation under reduced pressure
7. customThe residue was purified by silica gel column chromatography (chloroform)