huagongshe.com
HRID1853161

反应详情

EQUATION

反应方程式

HRID 1853161 的结构方程式

REACTANTS

反应物

2
结构：N#Cc1cc2cnc(Cl)nc2n1C1CCCC1
HCID58315415

未命名化合物

结构：CC(C)(C)[SiH2]OC(C)(C)c1ccc(N)nc1
HCID178455437

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[SiH2]OC(C)(C)c1ccc(Nc2ncc3cc(C#N)n(C4CCCC4)c3n2)nc1
HCID178455434

未命名化合物

收率 66%

PROCEDURE

实验过程

Following Buchwald Procedure A, 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonitrile (95 mg, 0.385 mmol) and 5-(tert-butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine (101 mg, 0.424 mmol) (Example C) gave 114 mg of 2-[5-(tert-butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamino]-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonitrile [following SiO2 chromatography eluting with 1-2% MeOH/dichloromethane and subsequent trituration with diethyl ether].