反应详情

Concentrated H2SO4 (4 mL) was added to tert-butyl 2-cyclohexyl-2-oxoethyl-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate (0.07 g, 0.14 mmol) and the reaction mixture was stirred for about 30 min at ambient temperature. The reaction mixture was poured onto ice-cold water (75 mL) and extracted with EtOAc (2×50 mL). The combined organic extracts were washed with brine, dried over anhydrous MgSO4, and concentrated to yield 8-cyclohexyl-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine as a yellow oil that was used in Example #9, Step C without further purification (0.051 g, 95%): LC/MS (Table 2, Method a) Rt=2.79 min; MS m/z: 395 (M+H)+.

1. additionThe reaction mixture was poured onto ice-cold water (75 mL)
2. extractionextracted with EtOAc (2×50 mL)
3. washThe combined organic extracts were washed with brine
4. dry with materialdried over anhydrous MgSO4
5. concentrationconcentrated