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HRID1854826

反应详情

EQUATION

反应方程式

HRID 1854826 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)c1cc(C2CC2)c2c(C)c(Cl)c(F)cn2c1=O
HCID9927245

未命名化合物

结构：CC1(C)OB(c2ccc(N)c(F)c2)OC1(C)C
HCID17906172

2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

C12H17BFNO2

PRODUCTS

生成物

1
结构：CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(N)c(F)c3)c(F)cn2c1=O
HCID86696544

未命名化合物

收率 10%

PROCEDURE

实验过程

Ethyl 8-(4-amino-3-fluoro-phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate was prepared according to General Procedure A using ethyl 8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate (149 mg, 0.46 mmol) and 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-aniline (134 mg, 0.58 mmol). Purification by flash silica column chromatography (CH2Cl2:MeOH) (1:0 to 9:1) afforded the title compound as a yellow solid (18 mg, 10%). ESI-MS m/z: 399 (M+H)+.

WORKUP

后处理

  1. customEthyl 8-(4-amino-3-fluoro-phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate was prepared
  2. customPurification by flash silica column chromatography (CH2Cl2:MeOH) (1:0 to 9:1)