反应详情

tert-Butyl 2-(2-(1-(3-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)ethoxy)acetate was prepared using a procedure analogous to tert-butyl 2-(2-(1-(3-phenoxyphenyl)-2-oxabicyclo[2.2.2]octan-4-yl)ethoxy)acetate except that 2-(1-(3-phenoxyphenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid was replace with methyl 2-(1-(3-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetate. The title compound was obtained (1 g, 2.24 mmol, 91% yield) as a clear oil. 1H NMR (500 MHz, CDCl3) δ 7.23-7.19 (m, 1H), 7.12-7.09 (m, 1H), 7.02-6.98 (m, 1H), 6.93 (ddd, J=8.3, 2.5, 0.8 Hz, 1H), 5.43 (t, J=3.3 Hz, 1H), 5.31 (s, 1H), 3.94 (s, 2H), 3.88-3.86 (m, 2H), 3.63-3.54 (m, 3H), 2.05-1.99 (m, 5H), 1.88-1.82 (m, 2H), 1.75-1.69 (m, 5H), 1.69-1.56 (m, 4H), 1.55-1.51 (m, 2H), 1.50 (s, 9H).

1. customtert-Butyl 2-(2-(1-(3-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)ethoxy)acetate was prepared