反应详情

温度

180 °C

A mixture of 200 mg (0.5 mmol) of 3-(2-bromophenyl)-7-methanesulfonyl-3,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-2(1H)-one and 208 mg (1 mmol) of 4-[2-(diethylamino)ethoxy]aniline was heated at 180° C. for 30 minutes and then cooled. The residue was subjected to column chromatography on silica gel using dichloromethane/methanol/acetic acid/water (240:24:3:2) for the elution. Product-containing fractions were combined and evaporated and the residue was evaporated with toluene. The residue was then dissolved in 40 ml of dichloromethane, washed with 40 ml of saturated aqueous sodium bicarbonate solution, dried over magnesium sulfate, filtered and evaporated to give 22 mg (8%) of 3-(2-bromophenyl)-7-[4-[2-(diethylamino)ethoxy]anilino]-3,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-2(1H)-one as a cream colored solid of melting point 144° C.

1. temperaturecooled
2. washfor the elution
3. customevaporated
4. customthe residue was evaporated with toluene
5. dissolutionThe residue was then dissolved in 40 ml of dichloromethane
6. washwashed with 40 ml of saturated aqueous sodium bicarbonate solution
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered
9. customevaporated