反应详情

A mixture of 0.90 g of 2-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}-6-benzyloxypyridine, 0.1 g of 10% palladium/carbon and 5 ml of ethyl acetate was stirred for 3 hours at room temperature under hydrogen atmosphere. The reaction system was purged with nitrogen, then, the reaction solution was filtrated through Celite, and the filtrate was concentrated. The residue was subjected to silica gel column chromatography to obtain 0.60 g of 6-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}-2-pyridone. 1H-NMR(CDCl3/250 MHz) δ(ppm): 3.54 (s, 3H), 6.11 (d, 1H, J=7.9 Hz), 6.33 (s, 1H), 6.44 (d, 1H, J=7.8 Hz), 7.09 (d, 1H, J=6.7 Hz), 7.37 (d, 1H, J=8.9 Hz), 7.55 (dd, 1H, J=7.9,7.8 Hz)

1. customThe reaction system was purged with nitrogen
2. filtrationthe reaction solution was filtrated through Celite
3. concentrationthe filtrate was concentrated