反应详情

The procedure described in Example 1 (preparation of starting materials) was repeated using (S)-(+)-1-amino-2-propanol and 5-fluoro-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]quinazolin-4-amine (obtained as described in Example 1, preparation of starting materials) to give 5-[(1S)-2-amino-1-methylethoxy]-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]quinazolin-4-amine in 46% yield; NMR spectrum (DMSO-d6) 1.39 (d, 3H), 2.96 (m, 2H), 4.79 (m, 1H), 5.28 (s, 2H), 7.17 (d, 1H), 7.21 (d, 1H), 7.29 (d, 1H), 7.35 (m, 1H), 7.56 (d, 1H), 7.64 (dd, 1H), 7.70 (t, 1H), 7.86 (dt, 1H), 8.20 (d, 1H), 8.48 (s, 1H), 8.58 (d, 1H), 10.60 (bs, 1H); Mass Spectrum MH+ 435.

1. customThe procedure described in Example 1 (preparation of starting materials)