HRID1864619

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18321448

未命名化合物

反应SMILES：Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc2oc(=O)[nH]c12

HCID68608307

未命名化合物

PRODUCTS

产物

反应SMILES：CC(=O)N1CCN(C2CCN(C(=O)[C@@H](Cc3cc(C)c4[nH]c(=O)oc4c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1

HCID16734707

未命名化合物

PROCEDURE

实验过程

Prepared analogously to Example 1 h from 600 mg (1.18 mmol) (R)-1-carboxy-2-(4-methyl-2-oxo-2,3-dihydrobenzoxazol-6-yl)-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate and 275 mg (1.30 mmol) 1-(4-piperidin-4-yl-piperazin-1-yl)-ethanone.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-b7fc03f8a88d4e46a676605502f35b23
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07625886B2
来源说明: uspto-grants-2009_12

反应SMILES

[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@@H:18]([C:31]([OH:33])=O)[CH2:19][C:20]3[CH:29]=[C:28]([CH3:30])[C:23]4[NH:24][C:25](=[O:27])[O:26][C:22]=4[CH:21]=3)=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:34]=[CH:35][CH:36]=[CH:37][C:4]=2[NH:3]1.[NH:38]1[CH2:43][CH2:42][CH:41]([N:44]2[CH2:49][CH2:48][N:47]([C:50](=[O:52])[CH3:51])[CH2:46][CH2:45]2)[CH2:40][CH2:39]1>>[O:1]=[C:2]1[N:8]([CH:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][C@H:18]([CH2:19][C:20]3[CH:29]=[C:28]([CH3:30])[C:23]4[NH:24][C:25](=[O:27])[O:26][C:22]=4[CH:21]=3)[C:31]([N:38]3[CH2:39][CH2:40][CH:41]([N:44]4[CH2:45][CH2:46][N:47]([C:50](=[O:52])[CH3:51])[CH2:48][CH2:49]4)[CH2:42][CH2:43]3)=[O:33])=[O:16])[CH2:13][CH2:14]2)[CH2:7][CH2:6][C:5]2[CH:34]=[CH:35][CH:36]=[CH:37][C:4]=2[NH:3]1