反应详情

Method I2 was used with 7-(4-aminophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one (25 mg, 0.1 mmol) and phenyl 3-tert-butyl-1-(4-fluorophenyl)-1H-pyrazol-5-yl-carbamate (42 mg, 0.12 mmol) to afford the title compound (18 mg, 35%). 1H-NMR (δ, ppm, DMSO-d6): 1.29 (s, 9H, t-Bu), 3.46 (s, 3H, CH3N), 6.37 (s, 1H, HPyz,4), 6.41 (d, 1H, HPy,6), 7.13 (d, 2H, Harom,Ph,3+5), 7.38 (t, 2H, Harom,4-F-Ph,3+5), 7.48 (d, 2H, Harom,Ph,2+6), 7.57 (dd, 2H, Harom,4-F-Ph,2+6), 7.80 (d, 1H, HPy,6), 8.38 (s, 1H, NHurea), 9.08 (s, 1H, NHurea), 11.61 (bs, 1H, NHPy3). LC-MS (m/z): 516 (M+H, 100). Acc. mass (C27H26N7O3F): calculated 516.2159, found 516.2086.