反应详情

A mixture of methyl 4′-[3-[(trifluoroacetyl)amino]-propyl]-1,1′-biphenyl-4-carboxylate (920 mg), 4N hydrochloride in ethanol (2 ml) and ethanol (2 ml) was refluxed for 18 hours. The mixture was evaporated in vacuo. The residue was diluted with ethyl acetate and saturated aqueous sodium bicarbonate solution. The organic layer was separated, washed with brine, dried over magnesium sulfate and evaporated. The residue was purified by column chromatography on silica gel (chloroform:methanol=100:1) to give ethyl 4′-(3-aminopropyl)-1,1′-biphenyl-4-carboxylate (200 mg) as a colorless foam.

1. temperaturewas refluxed for 18 hours
2. customThe mixture was evaporated in vacuo
3. additionThe residue was diluted with ethyl acetate and saturated aqueous sodium bicarbonate solution
4. customThe organic layer was separated
5. washwashed with brine
6. dry with materialdried over magnesium sulfate
7. customevaporated
8. customThe residue was purified by column chromatography on silica gel (chloroform:methanol=100:1)