HRID1873272

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：CC(C)(C)OC(=O)NN(Cc1ccc(-c2nnn(C(C)(C)c3ccccc3)n2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)C(F)(F)F

HCID22940454

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NN(Cc1ccc(-c2nnn(C(C)(C)c3ccccc3)n2)cc1)C[C@H](O)[C@@H](N)Cc1ccccc1

HCID22940451

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

28 ml of a 1N K2CO3 solution are added dropwise, at 70° C., to 1.9 g (2.8 mmol) of 1-{4-[2-(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-phenyl}-4(S)-hydroxy-2-(tert-butoxycarbonyl)amino-5(S)-(trifluoroacetyl)amino-6-phenyl-2-azahexane in 29 ml of methanol and the mixture is stirred for 15 hours. After cooling and concentration by evaporation, methylene chloride and water and added; the aqueous phase is separated off and extracted with methylene chloride. The organic phases are washed with water, dried (Na2SO4) and concentrated by evaporation to yield the title compound: HPLC20-100 : tRet =15.1; FAB MS (M+H)+ =469.

WORKUP

后处理

temperatureAfter cooling
concentrationconcentration
customby evaporation, methylene chloride and water
additionadded
customthe aqueous phase is separated off
extractionextracted with methylene chloride
washThe organic phases are washed with water
dry with materialdried (Na2SO4)
concentrationconcentrated by evaporation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a9168172cf924a5e8f1d3882d320a3ec
来源数据集: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06110946
来源说明: uspto-grants-2000_08

反应 SMILES

C([O-])([O-])=O.[K+].[K+].[CH3:7][C:8]([N:16]1[N:20]=[N:19][C:18]([C:21]2[CH:26]=[CH:25][C:24]([CH2:27][N:28]([NH:47][C:48]([O:50][C:51]([CH3:54])([CH3:53])[CH3:52])=[O:49])[CH2:29][C@H:30]([OH:46])[C@@H:31]([NH:39]C(=O)C(F)(F)F)[CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[CH:23][CH:22]=2)=[N:17]1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:9]>CO>[CH3:9][C:8]([N:16]1[N:20]=[N:19][C:18]([C:21]2[CH:26]=[CH:25][C:24]([CH2:27][N:28]([NH:47][C:48]([O:50][C:51]([CH3:54])([CH3:53])[CH3:52])=[O:49])[CH2:29][C@H:30]([OH:46])[C@@H:31]([NH2:39])[CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[CH:23][CH:22]=2)=[N:17]1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:7]