反应详情

17.1 g (43.0 mmol) of 2-(4′-ethyl-3-fluorobiphenyl-4-yl)-5-(pent-1-enyl)-selenophene are hydrogenated in 170 ml of ethyl acetate, in the presence of Pd/C (5% of Pd) at atmospheric pressure and RT. The reaction soln. is filtered and concentrated to dryness, and the crude product is purified by column chromatography (SiO2, n-heptane:toluene=98:2→95:5). The further purification is carried out by recrystallisation from ethanol and n-heptane. 2-(4′-Ethyl-3-fluorobiphenyl-4-yl)-5-pentylselenophene is obtained as a colourless solid (m.p. 52° C.).

1. filtrationis filtered
2. concentrationconcentrated to dryness
3. customthe crude product is purified by column chromatography (SiO2, n-heptane:toluene=98:2→95:5)
4. customThe further purification
5. customis carried out by recrystallisation from ethanol and n-heptane