反应详情

The title compound was prepared as described herein using 3-{[3-(aminomethyl)-2-chloro-6-fluorophenyl]oxy}-5-chlorobenzonitrile (40 mg, 0.129 mmol), 4-chloro-2-methyl-1H-imidazole-5-carboxylic acid (20.64 mg, 0.129 mmol), EDC (27.4 mg, 0.143 mmol) and HOBT (27.3 mg, 0.178 mmol) in DMF (3.0 ml) to give the title compound as a white solid (40 mg, 69%). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 10.42 (1H, br. s.) 7.46-7.54 (0H, m) 7.31-7.41 (2H, m) 7.16-7.23 (2H, m) 7.14 (1H, d, J=2.1 Hz) 7.00 (1H, s) 4.72 (2H, d, J=6.2 Hz) 2.41 (3H, s). LCMS: m/z 453 (M+1).

1. customThe title compound was prepared